2008 University of Houston Schedule/Results
| Date | Opponent | Location | TV | Time |
| 08/22/08 | Texas-San Antonio at Houston | Houston, Texas | | 7:00 p.m. CT |
| 08/29/08 | Houston at Sam Houston State | Huntsville, Texas | | 7:00 p.m. CT |
| 08/31/08 | Stephen F. Austin at Houston | Houston, Texas | | 1:00 p.m. CT |
| 09/05/08 | Louisiana-Lafayette at Houston | Houston, Texas | | 7:00 p.m. CT |
| 09/12/08 | Houston at Texas | Austin, Texas | | 7:00 p.m. CT |
| 09/14/08 | Houston at LSU | Baton Rouge, La. | | 1:00 p.m. CT |
| 09/19/08 | Houston at Texas State | San Marcos, Texas | | 7:00 p.m. CT |
| 09/21/08 | Houston at Baylor | Waco, Texas | | 1:00 p.m. CT |
| 09/26/08 | Marshall at Houston | Houston, Texas | | 7:00 p.m. CT |
| 09/28/08 | East Carolina at Houston | Houston, Texas | | 1:00 p.m. CT |
| 10/03/08 | Tulsa at Houston | Houston, Texas | | 7:00 p.m. CT |
| 10/05/08 | Houston at SMU | Houston, Texas | | 1:00 p.m. CT |
| 10/10/08 | Houston at Memphis | Memphis, Tenn. | | 7:00 p.m. CT |
| 10/12/08 | Houston at UAB | Birmingham, Ala. | | 2:00 p.m. CT |
| 10/17/08 | Houston at Southern Miss | Hattiesburg, Miss. | | 4:00 p.m. CT |
| 10/19/08 | Houston at UCF | Orlando, Fla. | | 1:00 p.m. CT |
| 10/24/08 | UTEP at Houston | Houston, Texas | | 5:00 p.m. CT |
| 10/26/08 | Houston at Colorado College | Colorado Springs, Colo. | | 12:00 p.m. CT |
| 10/31/08 | Rice at Houston | Houston, Texas | | 7:00 p.m. CT |
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